Related Products of 4640-67-9, A common heterocyclic compound, 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, molecular formula is C9H6FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 10 mL of sealed vial was added benzoyl acetonitrile derivatives 1 (0.5 mmol), malononitrile (0.55 mmol), SeO2 (42.6mg, 0.38 mmol), benzoic acid (30.5 mg, 0.25 mmol), CH3CN (2 mL) and a magnetic stir bar. The reaction mixture was stirred at room temperature for 12 h. The reaction mixture was filtered, and the residue was extracted with dichloromethane (3 × 15 mL). The combined organic phases was washed with brine (45 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatograph on silica gel to afford the desired product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.