Application of 16532-79-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16532-79-9 name is 4-Bromophenylacetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 8 Synthesis of N2- ( (1S)-L- {4 – [L- (AMINOCARBONYL) CYCLOPROPYL] BIPHENYL-4-YL}-2, 2, 2-TRIFLUOROETHYL)-NL-(L- cyanocyclopropyl) -4-fluoro-L-leucinamide Step 1 : Preparation of 1-(4-bromophenyl)cyclopropanecarbonitrile; To a room temperature solution of 4-bromophenylacetonitrile (18.0 g) in 22 ML of sodium hydroxide (50% in water W/W) were added 1-BROMO-2-CHLOROETHANE and (12.0 mL) and benzyltrimethylammonium chloride (627 mg). The mixture was heated at 60 C overnight. The reaction mixture was cooled to room temperature and diethyl ether was added (300 mL. The ether layer was washed with water (100 ML), hydrogen chloride (100 ML, 10% HC1 in water) and brine. The organic layer was dried with magnesium sulfate and the solvent removed in vacuo. The residue was purified by trituration using diethyl ether and hexanes to yield the title compound. H NMR (CD3COCD3) 8 7.60 (2H, d), 7.35 (2H, d), 1.74-1. 80 (2H, m), 1.52-1. 57 (2H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromophenylacetonitrile, and friends who are interested can also refer to it.