In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7048-38-6 as follows. Recommanded Product: (5-Chloro-2-methoxyphenyl)acetonitrile
To a solution of 2-(5-chloro-2-methoxyphenyl)acetonitrile (lOg, 47.84mmol) in ethyl formate (50mL) was added sodium metal (4.4g, 95.6mmol) at room temperature. The resulting reaction mixture was heated at 100°C for 3 hours. After completion of the reaction, it was cooled to room temperature, water (100ml) and dichloromethane (100ml) were added to the reaction mixture and the solution was adjusted to pH-3 with the help of concentrated hydrochloric acid. The layers were separated and the aqueous layer was extracted with dichloromethane (2 x 100ml). The combined organics were washed with saturated aqueous sodium chloride solution (150ml), dried over sodium sulphate, filtered and evaporated in vacuo. The crude product was purified by column chromatography using normal phase silica gel. The desired product eluted at around 0.7 to 0.9percent methanol in dichloromethane. Evaporation of the product fractions gave 9g (yield, 77.94percent) of the desired compound as a white solid. LC-MS: m/z = 208.0(M-H).
According to the analysis of related databases, 7048-38-6, the application of this compound in the production field has become more and more popular.