Reference of 668-45-1, The chemical industry reduces the impact on the environment during synthesis 668-45-1, name is 2-Chloro-6-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.
To a solution of A5.1 (1.55 g, 10.0 mmol) in 100 mL of anhydrous methanol was added sodium methoxide (4.32 g, 80 mmol). The mixture was heated at 85 oC and stirred overnight, then concentrated under reduced pressure to remove solvents. The residue was diluted with 400 mL DCM, washed with Sat. NH4Cl (2 × 20 mL), dried over anhydrous Na2SO4, concentrated under vacuum. The crude product was purified by column chromatography (PE:EA =10:1) to give the title compound (1.5 g, 89.8%) as a pale yellow solid. LC-MS: [MH]+ = 168.0
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.