Adding a certain compound to certain chemical reactions, such as: 17417-09-3, name is 2-Fluoro-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17417-09-3, Computed Properties of C7H3FN2O2
Under room temperature, into the 3-amino-4-fluorophenol (3 g, 22.42mmol) and 2-fluoro-5-nitrobenzonitrile (4.19 g, 24.66mmol) into DMF (20 mL) solution added K2CO3 (4.89g, 35.4mmol). The solution was stirred at 80C for 8h, and the solution was extracted with ethyl acetate, washed with saturated sodium chloride, drying with anhydrous sodium sulfate, filtering out insoluble matter, filter and concentrate under reduced pressure, the residue obtained was purified by silica gel column chromatography, (eluent: petroleum ether / ethyl acetate = 5:1 -4:1), and the resulting solution was concentrated under reduced pressure, obtained 1.95 g of a light yellow solid, yield is 35%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-5-nitrobenzonitrile, and friends who are interested can also refer to it.