In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 78881-21-7, name is 4-Amino-3-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H8N2
A solution of sodium nitrite (0.52 g, 7.57 mmol) in water (3 ml.) was added dropwise to a cold (0C) mixture of 4-amino-3-methylbenzonitrile (1 g, 7.57 mmol) and concentrated HCI (12 ml.) keeping the internal temperature below 0C. After 5 min stirring, tin dichloride dihydrate (3.75 g, 16.6 mmol) in concentrated HCI (4 ml.) was added at 0C. The reaction mixture was allowed to warm to rt and stirred for 2 h. The resulting precipitate was collected by vacuum filtration and dried to provide 500 mg of the title compound. tR: 0.24 min (LC-MS 2); ESI-MS: 148 [M+H]+(LC-MS 2).
The synthetic route of 78881-21-7 has been constantly updated, and we look forward to future research findings.