Application of 6629-04-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6629-04-5 name is N-Cyanoacetylurethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 18 (0.5 g, 1.58 mmol) and concentrated hydrochloric acid (7 ml) were added to water (15 ml), and the solution was dropped to 0.After C, an aqueous solution of sodium nitrite (0.143 g, 2.05 mmol, 2 ml) was slowly added dropwise to the above solution, and the reaction was carried out for 0.5 h.In a reactor, compound 10 (0.246 g, 1.58 mmol), pyridine (5 ml), water (15 ml) was added thereto, and the solution was lowered.To 0 C, then the reaction solution in the previous reactor was quickly poured into it, and the reaction was stirred for 0.5 h. After the reaction was completed, ethyl acetate(30 ml × 2) was extracted, and the organic phases were combined, dried, and dried to give an orange-yellow solid, 0.48 g, yield 63%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Cyanoacetylurethane, and friends who are interested can also refer to it.