The important role of 2-Chloro-4-fluoro-3-methylbenzonitrile

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 796600-15-2, its application will become more common.

Some common heterocyclic compound, 796600-15-2, name is 2-Chloro-4-fluoro-3-methylbenzonitrile, molecular formula is C8H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 796600-15-2

Heat a mixture of 2,4-dihydroxy-4-phenyl-l -butylamine (1.8 g, 10 mmol) and 2-chloro-4- fluoro-3-methyl-benzonitrile (1.0 g 6 mmol), cesium carbonate (4.Og, 12 mmol) and anhydrous dimethyl sulphoxide (10 ml) at 100 0C for 5 h. Allow the reaction cool and partition between ethyl acetate (100 ml) and water (3 x 50 ml). Wash the organic layer with 1.0M hydrochloric acid, dry over magnesium sulphate and concentrate to give a yellow oil (1.0 g). Dissolve this material in dichloromethane (20 ml) and treat with trifluoroacetic acid (5 ml). Allow the reaction mixture to stand at room temperature overnight and then wash with water (20 ml) and 2.0M sodium hydroxide (20 ml). Dry the organic layer over EPO magnesium sulphate and concentrate to dryness. Purify the residue by silica gel chromatography (eluting with 5 to 10% methanol / dichloromethane) to give 50 mg (1.6% yield as a single diastereoisomer) of the title compound as a white solid. MS: 313 [M C135+H]+ and 335 [M Cl35+Na]+; 1H NMR (300 MHz, CDCl3): delta 7.28 (m, 5H), 7.20 (d, IH), 6.72 (d, IH), 5.09 (m, IH), 4.60 (br m, IH), 4.29 (m, IH), 3.10 (m, IH), 2.44 (m, IH), 2.43 (s, 3H), 2.00 (m, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 796600-15-2, its application will become more common.