In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67515-59-7, name is 4-Fluoro-3-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 67515-59-7
A mixture of 4-fluro 3-trifluro-methylbenzonitrile (5 g, 26.4 mmol) and 2-methylpiperidine (6.25 ml_, 52.9 mmol) was heated at 10O C under N2 for 12h.The reaction mixture was diluted with water (100 ml_) and was extracted with EtOAc (2chi100ml_). The organic layer was washed with water (2chi100mL) and brine solution (10OmL). The solvent was dried over sodium sulphate and concentrated. The residue was purified by flash chromatography using silica-gel (60-120 mesh) and pet-ether /EtOAc as eluent to afford the title compound as an off-white solid. 1H NMR (CDCI3, 400 MHz) delta 7.87 (s, 1 H), 7.71 -7.74 (d, 1 H), 7.50 (bs, 1 H), 2.95-3.03 (m, 2H), 2.49-2.54 (m, 1 H), 1.71 -1 .77 (m, 3H), 1 .58-1.59 (m, 1 H), 1.36-1.39 (m, 2H), 0.75-0.77 (d, 3H). HPLC (Method C) Rt 5.09 min (Purity: 98.8%).
The synthetic route of 67515-59-7 has been constantly updated, and we look forward to future research findings.