Application of 103146-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 103146-25-4 name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
350 ml of isopropyl alcohol was charged to the residue and heated and stirred, then cooled to room temperature. 35 gm of (+)-DPTTA was added to the above solution and stirred for one hour at room temperature to isolation of the solid. The reaction mixture was heated to about 40-45 C, stirred for about 2 hours. The reaction mixture was cooled to room temperature, filtered the solid and dried to get 39 gm of the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, and friends who are interested can also refer to it.