Application of 3759-28-2,Some common heterocyclic compound, 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, molecular formula is C9H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
100ml of water was added to the reaction vessel, 20mmol (o-cyanophenyl)acetonitrile, 50mmolof potassium (naphthalene-2-yl)trifluoroborate, 0.8mmol palladium acetylacetonate, 2mmol nitrogen ligands L-1, and p-toluenesulfonic acid monohydrate 150mmol at 100 deg.] C under stirring for 20 hours.After completion of the reaction, the mixture was poured into ethyl acetate, sequentially with saturated NaHCO3aqueoussolution and brine, the aqueous layer was extracted with ethyl acetate, the combined organic layers (i.e., wash the combinedorganic layer and the extract obtained after the organic layer), dried over anhydrous of Na2the SO4dried, vacuum evaporatedsolvent was removed and the residue was purified by flash column chromatography (hexane / ethyl acetate, volume ratio of between1: 1) to give the desired product as a solid .The yield was 59.6%,% purity was 98.4(the HPLC).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Cyanomethyl)benzonitrile, its application will become more common.