Application of 23842-82-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23842-82-2 as follows.
General procedure: Matrine 1 (1.24 g, 5 mmol) dissolved in DCM (30 mL) was treatedwith POCl3 (2 eq., 10 mmol) at room temperature. When color of thereaction mixture turned yellow, it was then stirred at 60 C for 2-3 h.The solution was then cooled to room temperature and the correspondinganiline bearing cyan derivatives 18a-h (1-1.5 eq.) dissolvedin DCM were added dropwise, followed by reflux for 12 h at 60C. Afterreaction completion, NaOH aqueous was added to adjust the pH to 8-9.The mixture was then extracted with DCM (3 × 20 mL). The organiclayers were collected, dried over MgSO4, and concentrated. The residuewas purified by column chromatography to obtain product 20a-h.
According to the analysis of related databases, 23842-82-2, the application of this compound in the production field has become more and more popular.