Some common heterocyclic compound, 4210-32-6, name is 4-(tert-Butyl)benzonitrile, molecular formula is C11H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-(tert-Butyl)benzonitrile
General procedure: To a solution of adiponitrile (219 muL, 1.95 mmol) and the appropriate mononitrile (1.30 mmol) in p-xylene (1 mL) in a carousel tube was added t-BuOK (29.2 mg, 0.26 mmol) in one portion. The reaction vessel was heated in a carousel to 120 °C for 4 h. After cooling to room temperature, CH2Cl2 (ca. 30 mL) was used to transfer the mixture onto a silica cartridge for purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4210-32-6, its application will become more common.