Adding a certain compound to certain chemical reactions, such as: 35202-54-1, name is 4,5-Dimethoxy-1-cyanobenzocyclobutane, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35202-54-1, name: 4,5-Dimethoxy-1-cyanobenzocyclobutane
EXAMPLE 4 (R,S)-3,4-Dimethoxy-bicyclo[4.2.0]octa-4,3,5-triene-7-carbaldehyde 10 g (52.8 mmol) of 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile are dissolved in 100 ml of anhydrous toluene. The solution is cooled to -78° C. and then 55 ml of diisobutylaluminum hydride solution (1.2M in toluene) are added dropwise while maintaining the temperature below -65° C. (addition time=45 minutes). Stirring is carried out for 1 hour at -78° C. once the addition is complete. Hydrolysis is carried out by adding dropwise 20 ml of methanol. The temperature is allowed to return to -30° C. and then the reaction mixture is added to 200 ml of HCl (0.1N) and extraction with ether is carried out twice. The organic phase is washed in succession with water and saturated aqueous NaCl solution and then dried over MgSO4, filtered and evaporated to dryness to obtain 8 g of title product in the form of pale yellow oil. Yield=79percent IR (pure): nu=2714, 2630, 1712 cm-1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Dimethoxy-1-cyanobenzocyclobutane, other downstream synthetic routes, hurry up and to see.