Electric Literature of 120315-65-3, These common heterocyclic compound, 120315-65-3, name is 4-Bromo-3-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 4-bromo-3-methoxybenzonitrile(lg, 4.72 mmol), 4,4,4′,4′,5,5,5′,5′- octamethyl-2,2′-bi(l,3,2-dioxaborolane) (1.796 g, 7.07 mmol), K3P04 (1.157 g, 11.79 mmol) and PdCl2(dppf) CH2C12 adduct (0.207 g, 0.283 mmol) in dioxane (12 mL) was degassed and then heated at 90 C for 3 h. The reaction was cooled to rt and was filtered through a pad of CELITE. The solvent was removed. Normal phase chromatography afforded X-lb as brown oil (1.7 g, 5.76 mmol, 100%). LC-MS (ESI) of the boronic acid m/z: 178.0 [M+H]+.
Statistics shows that 4-Bromo-3-methoxybenzonitrile is playing an increasingly important role. we look forward to future research findings about 120315-65-3.