Reference of 261951-81-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261951-81-9, name is 3-Fluoro-2-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 3-fluoro-2- (trifluoromethyl)benzonitrile g, 6.3 mmol) and piperazine (0.72 g, 8,4 mmol) in acetonitrile (6 ml) was heated under microwave radiation at 150 C for 15 minutes. The reaction mixture was poured into water (50 ml) and the aqueous phase was extracted with ethylacetate (3×50 ml). The combined organic phases was dried (MgS04), filtered and evaporated to dryness. Purification by flash column chromatography (ethylacetate/methanol, 1:1) gave the title compound: 1.1 g. MS m/z (rel. intensity, 70 eV) 255 (M+, 16), 214 (11), 213 (bp), 171 (8), 151 (7).
The synthetic route of 3-Fluoro-2-(trifluoromethyl)benzonitrile has been constantly updated, and we look forward to future research findings.