In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92616-49-4, name is 4-Bromo-1-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C11H6BrN
Under N2 atmosphere, bis(pinacolato)diboron (8.4g, 33mmol), potassium acetate (6.5g, 66mmol) and [1,1?-bis(diphenylphosphine)ferrocene]palladium dichloride (1.2g, 1.76mmol) were respectively added to a solution of compound3-d (5.1g, 22mmol) in dioxane (150mL), the mixture was stirred at 80C for 6hrs. The mixture was evaporatedunder reduced pressure, the residue was filtered through celite, the filtrate cake was washed with dioxane (50mL), thefiltrate was evaporated under reduced pressure. The residue was purified with silica column chromatography (PE:EA =10:1) to give compound 3-c (6 g, yield 97%). LC-MS (ESI): m/z = 280 [M+H]+.
The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.