In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3215-64-3, name is 2-(2,6-Dichlorophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(2,6-Dichlorophenyl)acetonitrile
4-Methylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (22.00 g, 120.1 mmol) and 2, 6-DICHLOROPHENYLACETONITRILE (26.90 g, 144.6 mmol) were added to a dry 1 L three- necked flask equipped with an overhead stirrer. The solids were dissolved in 125 mL of dry DMF. The pale yellow solution turned slightly orange upon addition of 70 g (506 mmol) OF K2C03. The reaction was heated to 100C and stirred for 18 hours at this temperature. The reaction became dark reddish-orange in color. The flask was cooled to 50C and the resulting precipitate was filtered. The pink solid was washed with 100 mL of 3: 1 DMF/water. After vacuum drying, 13.45 g (32 %) OF 6- (2, 6-dichloro-phenyl) -8- METHYL-2-METHYLSULFANYL-8H-PYRIDO [2, 3-d] pyrimidin-7-ylideneamine were obtained. The spectral data matched literature values.
The synthetic route of 3215-64-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; WO2004/63195; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts