Adding a certain compound to certain chemical reactions, such as: 3215-64-3, name is 2-(2,6-Dichlorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3215-64-3, SDS of cas: 3215-64-3
The compound 2 – (2, 6 – dichlorophenyl) b nitrile (3.06 g, 16.4 mmol) dissolved in DMF (60 ml) in, then added to the reaction solution in the t – BuOK (1.84 g, 16.4 mmol), heating to 50 C, stirring reaction for 50 minutes, then slowly added to the reaction solution in 5 – bromo -1 – (phenyl-sulfonyl) – 1H – pyrrolo [2, 3 – b] pyridine -3 – formaldehyde (5 g, 13.7 mmol) in DMF (100 ml) solution, 1.5 hours after the completion of the dropping, the reaction solution in 50 C stirring overnight, then cooling to room temperature, the addition of water (20 ml) quenching the reaction, concentrated under reduced pressure, then adding EtOAc (200 ml) and water (100 ml) diluted residue, for a mixture of EtOAc (100 mLx 3) extraction, the combined organic phase for salt water (200 ml) washing, anhydrous Na2 SO4 Drying, concentrated under reduced pressure, the residue by silica gel column chromatography (PE/EtOAc (v/v)=4/1) to obtain the title compound (1 a and 1 b of the mixture) as a yellow solid (1.26 g, 24%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2,6-Dichlorophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; (88 pag.)CN104119331; (2018); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts