In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H3FN2O2
4-Fluoro-3-nitrobenzonitrile (1) (2 g, 0.012 mol) in ethyl acetate(50 mL) was supplemented with stannous chloride (11.4 g,0.06 mol). The reaction mixture was stirred for 30 min and then a saturated solution of sodium hydrogenocarbonate (100 mL) was added. This mixture was treated with ethyl acetate (300 mL) andthe aqueous layer was separated. The ethyl acetate layer was evaporated under reduced pressure. The crude product was dissolved in methanol, and ice was added; the resulting precipitate was collected by filtration (Yield: 30e60%).
The synthetic route of 1009-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bambi-Nyanguile, Sylvie-Mireille; Hanson, Julien; Ooms, Annie; Alpan, Lutfiye; Kolh, Philippe; Dogne, Jean-Michel; Pirotte, Bernard; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 32 – 40;,
Nitrile – Wikipedia,
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