Electric Literature of 50397-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50397-74-5, name is 4-Amino-3-bromobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1 :- Preperation of (E)-methyl 3-(2-amino-5-cyanophenyl)acrylate To a mixture of 4-amino-3-bromobenzonitrile (10.0 g, 0.050 mmol) and methyl acrylate (9.19 mL, 0.101 mmol) in acetonitrile (200 mL) was added palladium acetate (0.568 g, 0.0025 mmol) and tri-o-tolyl phosphine (1.54 g, 0.005 mmol) and Et3N (14.64 mL, 0.105 mmol). The reaction mixture was heated to reflux for 48 h. The reaction mass was filtered through celite and washed the bed with ethyl acetate. The filtrate was concentrated to afford 6.0 g of title product. 1H NMR (300 MHz, DMSO): delta 7.92 (s, 1H), 7.82-7.77 (d, = 15.6 Hz, 1H), 7.41-7.38 (d, = 8.7 Hz, 1H), 6.77- 6.74(d, = 8.7 Hz, 1H), 6.64 (s, 2H), 6.56-6.51 (d, = 15.6 Hz, 1H), 3.70 (s, 3H).
The synthetic route of 4-Amino-3-bromobenzonitrile has been constantly updated, and we look forward to future research findings.