Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C7H5ClN2
3-phenylpropiolic acid(185 mg, 1.27 mmol) was suspended in dichloromethane (1.9 ml), there to oxalyl chloride (0.114 ml, 1.33 mmol), and stirred for 2 hours at room temperature was added a DMF (1 drop). Thereto 2-amino-4-chlorobenzonitrile (194 mg, 1.27 mmol) and stirred overnight at room temperature added. After the reaction, water was added. Through a diatomaceous earth column (VARIAN Chem Elute 12198006), it was washed with chloroform. The solvent was distilled off and the residue was purified by silica gel column chromatography (SNAP 25 g, hexane / ethyl acetate) to give the title compound (268 mg, 75.2%) as a pale yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.