Analyzing the synthesis route of 2-Amino-3,5-dibromobenzonitrile

According to the analysis of related databases, 68385-95-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68385-95-5, name is 2-Amino-3,5-dibromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Amino-3,5-dibromobenzonitrile

General procedure: 4.3.1. General procedure for tacrine analogs. To a mixture of 2-amino-3,5-dibromobenzonitrile (1.0 mmol) and ketone (1.10 mmol) in toluene (12 mL) placed in a round bottom flask connected to a reflux condenser was added Lewis acid (1.20 mmol). The mixture was heated at 120 C for 24 h under stirring. After cooling to room temperature, the remaining solids were treated with NaOH solution (2 mol L-1, 12 mL) and this mixture was heated at reflux for 24 h. On cooling to room temperature, the reaction mixture was extracted with CHCl3 (3*25 mL), and the organic layers were combined and dried over Na2SO4. The solvent was evaporated under reduced pressure to give the desired product. The procedures were performed under an argon atmosphere in the presence of ZnCl2, InCl3, FeCl3, and BiCl3. The isolated products appeared to be sufficiently clean and no further purification was conducted.

According to the analysis of related databases, 68385-95-5, the application of this compound in the production field has become more and more popular.