Related Products of 40497-11-8,Some common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 104; 5-amino-1-[2, 6-dichloro-4-(trifluoromethoxy) phenyl]-1 H-pyrazole-3-carbonitrile To sulphuric acid (18M, 54 mi) was added sodium nitrite (13.9 g, 201.2 mmol) and the solution was stirred at 15C for 1 h. To the solution was added acetic acid (200 ml), followed by 2, 6-dichloro-4- (trifluoromethoxy) aniline (45.0 g, 182.9 mmol) in acetic acid (90 ml), ensuring the temperature of the solution did not rise above 20C. After addition was complete, the mixture was heated at 50C for 1 h, cooled to room temperature and added dropwise to a solution of ethyl 2,3-dicyanopropanoate (Hainzl, D.; Cole, L. M. ; Casida, J. E. Chemical Research in Toxicology (1998), 11 (12), 1529-1535,27. 8 g, 182.9 mmol) in acetic acid (115 ml) and ice cold water (145 ml). The reaction mixture was then stirred overnight at room temperature. To the reaction mixture was added dichloromethane (500 mi) and the mixture was stirred for 10 min. The two phases were separated and the organic phase was washed with water (200 mi) and ammonia (0.88, 400 ml) was added dropwise, maintaining the temperature of the mixture below 10C. This mixture was stirred overnight at room temperature and the organic phase was separated and concentrated in vacuo. The residue was re-crystallised from toluene/pentane [2: 1] to give the titled compound (22.4 g). Experimental MH+ 337.0 ; expected 337.0
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2,3-dicyanopropanoate, its application will become more common.