1835-49-0, name is Tetrafluoroterephthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8F4N2
About 1.25 g (about 6.25 mmol) of the 1,4-dicyano-2,3,5,6-tetrafluorobenzene synthesized according to the procedure described in Example 1 was transferred into about 57.5 mL of N2 bubbled toluene, which was at about 0 C. About 17.5 ml (about 17.5 mmol) of 1 M DIBAL-H (diisopropylaluminumhydride) toluene solution was added. After the reaction mixture was stirred for about 2.5 hours at room temperature, the mixture was cooled to about 0 C.About 30 mL of about 2 N HCl was added until the pH of the mixture was less than about 2 units.The aqueous layer was then extracted several times with CH2Cl2.The organic layer was combined and dried by evaporation.The crude product was chromatographed with toluene as a carrier through silica gel and produced about 0.79 g of product (about 62%).The 1H NMR resonance of this product in CDCl3 was delta 10.36 and the 19F NMR resonance was delta -144.1 (singlet).The reaction scheme (5) is illustrated below.
The synthetic route of 1835-49-0 has been constantly updated, and we look forward to future research findings.