Application of 53312-81-5, The chemical industry reduces the impact on the environment during synthesis 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.
AM-1 -1 CN AM-1-1 amine To a solution of AM-1 -1_CN (1.36 g, 10 mmol) in MeOH (50 mL) was added CoCI2.6H20 (4.7 g, 20 mmol). NaBH4 (1.13 g, 30 mmol) was added in portions to the above mixture at 0 C. The reaction mixture was warmed to r.t. and continued stirring for 12 hrs. The reaction mixture was made pH=13 with NH3.H20 and extracted with EA. The combined organic layer was washed with brine, dried over Na2S04 and concentrated. The crude was purified by column chromatography on silica gel (DCM / MeOH, 9:1 ) to give the product (0.6 g, 43%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-2-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.