Related Products of 6575-12-8, A common heterocyclic compound, 6575-12-8, name is 2,6-Dibromobenzonitrile, molecular formula is C7H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Embodiment 14 (S,E)-3-(4-((2-Hydroxymethylpyrrolidin-1-yl)methyl)-3,5-dimethoxystyryl)b iphenyl-2-carbonitrile 14 Synthesis of compound 14-c Phenylboronic acid (363mg, 3mmol) and 2,6-dibromobenzonitrile (783mg, 3mmol) were dissolved in a mixed solvent of 1,4-dioxane (20mL) and water (4mL), followed by addition of [1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (171mg, 0.21mmol) and sodium carbonate (1.06g, 10mmol). After the reaction system was purged three times with nitrogen, the reaction solution was heated to 80C and stirred for 16 hours. Then the reaction solution was cooled to room temperature and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether) to give compound 14-c (280mg, yield 36%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.