Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4475-95-0, name is 2-Amino-2-methylbutanenitrile, A new synthetic method of this compound is introduced below., SDS of cas: 4475-95-0
5:00 g (50.94 mmol) of 2-amino-2-methylbutanonitril [synthesis described in: Lonza AG, US 5,698,704 (1997);Deng, SL et al.Synthesis 2001, 2445;Hjorringgaard, CU et al.. J. Org. Chem 2009, 74, 1329;Ogrel, A. et al.EUR. J. Org. Chem. 2000, 857] were introduced into 50 ml of THF and 6.5 ml of water, 21.83 g (157.92 mmol) of potassium carbonate and treated at 0 C slowly with 7.9 ml (56.04 mmol) Benzylchlorocarbonat (benzylchloroformate) ,After addition of 8 ml THF and 3 ml of water, the reaction mixture was stirred slowly at RT coming overnight.Then was treated with water and extracted three times with ethyl acetate.The combined organic phases were dried over sodium sulfate and concentrated.The residue was dissolved in diethyl ether and precipitated with petroleum ether.The product was filtered off, the solid washed with a little petroleum ether and dried under high vacuum.There were 11:35 g of the target compound (93%. Th.)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.