Reference of 213598-11-9,Some common heterocyclic compound, 213598-11-9, name is Methyl 3-cyano-4-isopropoxybenzoate, molecular formula is C12H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4) 50L reaction kettle to add the previous step crude,2N sodium hydroxide (5 L), tetrahydrofuran (2 L) and stirred at 60 C for 1 hourTime. After cooling to room temperature, the mixture was extracted by intermittent stirring, the aqueous solution was extracted into the water phase and the ethyl acetate was taken as the organic phase. The extraction temperatureDegree of stirring, the extractant ethyl acetate and 3-cyano-4-isopropoxybenzoic acid aqueous solution contact; compared to the organic phase / aqueous phase =1, extraction temperature 37 , extraction time = 18 minutes, continuous extraction 3 times, the separation of the aqueous phase, the organic phase was distilled off under reduced pressure, analysisA large amount of white solid was obtained to give 1.1 kg of white solid. The yield was 84% in two steps and 98.5% by HPLC.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-cyano-4-isopropoxybenzoate, its application will become more common.