Electric Literature of 228421-83-8, A common heterocyclic compound, 228421-83-8, name is 3,5-Difluoro-4-(hydroxymethyl)benzonitrile, molecular formula is C8H5F2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To an ice cooled solution [OF 2, 6-DIFLUORO-4-HYDROXYMETHYLBENZONITRILE] (1.24 g, 7.32 mmol; see step (iii) above) and methanesulfonyl chloride (0.93 g, 8.1 mmol) in 60 mL of methylene chloride was added triethylamine (0.81 g, 8.1 mmol) with stirring. After 3 h at [0C,] the mixture was washed twice with 1M HCI and once with water, dried [(NA2SO4)] and evaporated. The product could be used without further purification. Yield: 1.61 g (89%). ‘H NMR (300 MHz, [CDCI3)] [5] 7.29 (m, 2H), 5.33 (s, 2H), 3.07 (s, 3H)
The synthetic route of 228421-83-8 has been constantly updated, and we look forward to future research findings.