In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 149793-69-1, name is 3-Fluoro-5-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 149793-69-1
A mixture of [3-FLUORO-5- (TRIFLUOROMETHYL)-BENZONITRILE (LANCASTER] Synthesis GmbH; 17 g, 89 [MMOL)] and 2-methylimidazole (Fluka, Buchs, Switzerland ; 22.2 g, 270 [MMOL)] in N, N- dimethylacetamide (80 mL) is stirred at [145C] for 19 h. The solvent is evaporated off under reduced pressure and the residue is dissolved in ethyl acetate (200 mL). The solution is washed with brine (200 mL), dried [(NA2SO4)] and the solvent is evaporated off under reduced pressure to give the crude product which is purified by recrystallisation from ether-hexane to afford the title compound as yellow crystalline solid, m. p. [132-134C.]
The synthetic route of 149793-69-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/5281; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts