Related Products of 29509-06-6, The chemical industry reduces the impact on the environment during synthesis 29509-06-6, name is 4-Methyl-3-oxopentanenitrile, I believe this compound will play a more active role in future production and life.
7-A. 5-Isopropyl-isoxazol-3-ylamine.; To a mixture of 4-methyl-3-oxopentanenitrile (11 g, 99 mmol) and water (200 mL) is added NaOH (4.95 g, 124 mmol). Once the NaOH pellets are completely dissolved, hydroxylamine sulfate (8.93 g, 109 mmol) is added and after 5 min the pH is measured (pH 7-8). The reaction is warmed to 40 0C and stirred for 72 h. At this point HCI (13.0 mL, 158 mmol, 37%) is added in one portion and the reaction warmed to 50 0C for 2.5 h. The reaction is removed from the oil bath and allowed to cool to rt. At this point a solution of NaOH (30% in H2O) is added to give a solution of pH 1 1. EtOAc is then added and the layers separated. The water layer is extracted with EtOAc (3 x) until no more product appears in the LCMS of the water layer. The combined organics are dried (Na2SO4) and evaporated to give 5-isopropyl- isoxazol-3-ylamine. MS (ESI) m/z 127.2 (M+1 ).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-oxopentanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; ARTMAN III, Gerald David; ELLIOTT, Jason Matthew; JI, Nan; LIU, Donglei; MA, Fupeng; MAINOLFI, Nello; MEREDITH, Erik; MIRANDA, Karl; POWERS, James J.; RAO, Chang; WO2010/66684; (2010); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts