The important role of 2-Nitrobenzonitrile

The synthetic route of 612-24-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 612-24-8,Some common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, molecular formula is C7H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a suspension of a respective 2-nitro-benzonitrile 3a,b or 7a,b (15 mmol) in water (10 mL) was added sodium dithionite (60 mmol), and the reaction mixture was heated to 50C and stirred at this temperature for 3-4 h. Then, the temperature was raised to 65C and concentrated HCl (5 mL) was added dropwise in 30 min. The resulting mixture was cooled to 20C, and the pH was adjusted to ~10 using 50% aqueous sodium hydroxide solution. The formed precipitate was filtered, washed with cold water, n-hexane, and dried at 40oC to afford 2-nitro-benzonitriles 8a-d, respectively.

The synthetic route of 612-24-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Le-Nhat-Thuy, Giang; Dinh, Thuy Van; Pham-The, Hai; Nguyen Quang, Hung; Nguyen Thi, Nga; Dang Thi, Tuyet Anh; Hoang Thi, Phuong; Le Thi, Tu Anh; Nguyen, Ha Thanh; Nguyen Thanh, Phuong; Le Duc, Trung; Nguyen, Tuyen Van; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3741 – 3747;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts