Some scientific research about 2-Chloro-4-fluoro-3-methylbenzonitrile

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-4-fluoro-3-methylbenzonitrile. I believe this compound will play a more active role in future production and life.

Electric Literature of 796600-15-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 796600-15-2, name is 2-Chloro-4-fluoro-3-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Heat a slurry of 2-chloro-4-fluoro-3-methyl-benzonitrile (0.4 g, 2.36 mmol) and L-proline (2.11 g, 18.8 mmol) in N-methylmorpholine (1.6 mL) at 200 0C in a microwave for 30 min. Partition the reaction between 2N aqueous hydrochloric acid and ethyl acetate. Separate and extract the organic portion with 2N aqueous sodium hydroxide. Acidify the aqueous extract to pH 1 by adding concentrated EPO hydrochloric acid and back extract into ethyl acetate. Extract the combined organic portions with brine, dry over magnesium sulphate, filter, and concentrate under reduced pressure to give the title compound. (0.395 g, 63%) mass spectrum (m/e): 263(M-I); 1H NMR (300 MHz, CDCl3): delta 8.66(bs,lH0, 7.31(d, IH), 6.75(d, IH), 4.38(t,lH), 3.67(m, IH), 3.10(m,lH), 2.43(m,lH), 2.29(s,3H), 2.20-1.90(m.3H).

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-4-fluoro-3-methylbenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/124447; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts