Related Products of 6952-59-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6952-59-6 name is 3-Bromobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred mixture of aryl or heteroaryl halide(Br, I) (0.5 mmol), potassium mono ethyl malonate (0.75 mmol) in THF (10 mL) taken in a 30 mL microwave vial, was added Pd(OAc)2(5 mol%), Xantphos (5 mol %), MgCl2 (0.75), Et3N ( 0.75mmol), imidazole (1 mmol) followed by Co2(CO)8 (0.15mmol). The vial was sealed immediately and microwave irradiated at 90C for 30min. The reaction mixture was concentrated and diluted with ethyl acetate and water. The ethyl acetate layer was separated, dried over sodium sulphate and concentrated. The crude product obtained was purified by column chromatography to get the pure compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromobenzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Baburajan, Poongavanam; Elango, Kuppanagounder P.; Tetrahedron Letters; vol. 55; 25; (2014); p. 3525 – 3528;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts