Adding a certain compound to certain chemical reactions, such as: 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 194853-86-6, Quality Control of 4-Fluoro-2-(trifluoromethyl)benzonitrile
4-fluoro-2-trifluorobenzonitrile (55) (994 mg),5,5-dimethylhydantoin (56) (3.37 g),Potassium carbonate (1.11 g) was added to N, N-dimethylformamide (15 mL) and stirred under nitrogen atmosphere at 45 C. for 42 hours.After returning the reaction solution to room temperature, the reaction solution was diluted with ethyl acetate and washed with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The obtained residue was purified by silica gel flash column chromatography (developing solvent: chloroform: methanol = 50: 1) to give the title compound (57) (503 mg, yield 32.2%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-2-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Kyoto prefectural public university; Suzuki, Takasada; Ito, Yukihiro; Ota, Yosuke; (55 pag.)JP2017/71567; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts