Application of 6330-25-2, These common heterocyclic compound, 6330-25-2, name is 2-Cyano-N-methyl-acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N -Methyl 2-amino-5-(2-(4-methoxyphenyl)ethyl)thiophene-3-carboxamide (TJ19). To a mixture of 4-(4-methoxyphenyl)butanal 6 (0.5 g, 2.805 mmol), 2-cyano-N- methylacetamide 8 (0.275 g, 2.805 mmol) and sulfur (0.090g, 2.805 mmol) in DMF (10 mL), NEt3(0.851 g, 8.451 mmol, 3 equiv) was added. After stirring the resulting mixture at 60C for 30 hrs, the reaction mixture was added to water (20 mL). Ethyl acetate (20 mL) was added and the organic solution was washed with distilled water (3 chi 20 mL), dried over MgS04, filtered, and then evaporated to dryness to afford the crude product mixture. Purification by column chromatography (silica, eluent CH2CI2- ethyl acetate 90-10) afforded TJ19 (0.27 g, 33%) as an off-white solid. 1H NMR (300 MHz, CDCI3) deltaEta 2.86 (m, 7H); 3.78(s, 3H); 5.57 (s, 2H); 6.64(s, 1 H); 6.81 (d, 2H); 7.06(d, 2H).
Statistics shows that 2-Cyano-N-methyl-acetamide is playing an increasingly important role. we look forward to future research findings about 6330-25-2.
Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; UNIVERSITA DEGLI STUDI DI FERRARA; BALZARINI, Jan; DEHAEN, Wim; THOMAS, Joice; LIEKENS, Sandra; ROMAGNOLI, Romeo; BARALDI, Pier Giovanni; WO2013/190137; (2013); A2;,
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