Related Products of 939-79-7, The chemical industry reduces the impact on the environment during synthesis 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
Furan-2,5-dicarboxaldehyde (197mg, 1.6mmol) and 4-cyano-2-nitrotoluene (12; 600mg, 3.7mmol) were dissolved in sulfolane (1mL) to which was added piperidine (200 muL, 2.0mmol). The mixture was heated to 150C in a sealed tube for 30min, producing a dark suspension. The reaction was cooled to room temperature, and MeOH (5mL) and Et2O (5mL) were added. The solids were triturated, filtered, rinsed with Et2O, and dried to yield 417mg (64%) of product as a brown powder. Material is too insoluble for 1H NMR evaluation.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Williams, John D.; Nguyen, Son T.; Gu, Shen; Ding, Xiaoyuan; Butler, Michelle M.; Tashjian, Tommy F.; Opperman, Timothy J.; Panchal, Rekha G.; Bavari, Sina; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7790 – 7806;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts