Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 127667-01-0
2-Fluoro-5-methoxy benzonitrile (70 mg, 0.46 mmol, 1.0 equiv.) and hydrazine monohydrate (0.3 ml, 6.0 mmol, 13.0 equiv.) were mixed in n-BuOH (2 ml) and heated the reaction mixture in a microwave oven at 180 0C for 45 mins. After it cooled to room temperature, the product indazole amine was precipitated (purified) by addition of n-hexane or n-heptane solvent. Further the precipitated solid was purified using MeOH: CH2Cl2 (1 :1) solvent. The solid was washed with little water (to remove the excess hydrazine), and was dried for couple of hours to obtain nice crystalline white solid of indazole amine (46 mg) in 60 % yield. HPLC: Shim-pack VP ODS 4.6 x 50 m column, Water: MeOH; 0.1% TFA, RT =1.38; LC-MS; M+H+ = 164.2.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; WO2008/89307; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts