Related Products of 1897-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1897-52-5, name is 2,6-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1: Preparation of 2,6-difluorobenzenecarboximidamide: To a solution of 2,6-difluorobenzonitrile (20 g) in diethyl ether (200 mL) was added lithium bis(trimethylsilyl)amide (240 mL, 1M in THF) at 0 C. The reaction mixture was stirred overnight at room temperature. After that, methyl tert-butyl ether (150 mL) was added and the reaction was stirred for 10 min. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (2×50 mL). The aqueous layer was basified (pH: 12-14) and extracted with ethyl acetate (2×50 mL). The combined organic layer was dried over sodium sulphate and concentrated under reduced pressure to afford the title compound (16 g) as a white solid. ‘H-NMR (400.0 MHz, de-DMSO): delta = 7.46-7.38 (m, 1H), 7.13-7.08 (m, 2H), 6.51 (s large, 3H).
The synthetic route of 2,6-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; SCHWARZ, Hans-Georg; DECOR, Anne; GREUL, Joerg; TRAUTWEIN, Axel; HEILMANN, Eike Kevin; FISCHER, Reiner; LOeSEL, Peter; MALSAM, Olga; PORTZ, Daniela; ILG, Kerstin; SOMMER, Herbert; EILMUS, Sascha; SCHARWEY, Melanie; LISHCHYNSKYI, Anton; GEIBEL, Sven; GOeRGENS, Ulrich; HERBERT, Simon; TURBERG, Andreas; (124 pag.)WO2017/5717; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts