Synthetic Route of 621-50-1, The chemical industry reduces the impact on the environment during synthesis 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, I believe this compound will play a more active role in future production and life.
To an ice-cold slurry of 50% sodium hydride (2.17g, 90.4mmol) in anhydrous THF (15ml), was slowly added a solution of (3-nitro-phenyl)-acetonitrile (2.2g, 13.58mmol) in anhydrous THF (5ml). After 30 min, methyl iodide (6.67ml, 107mmol) was slowly added. The reaction mixture was allowed to warm to room temperature and stirred overnight. It was then quenched with ice- water. The compound was then extracted with ethyl acetate, the organic layer separated and washed with water, dried over anhydrous sodium sulphate, filtered and concentrated to oil. Column chromatography over silica gel by eluting with ethyl acetate/pet ether (5:95) gave 2-methyl-2-(3-nitrophenyl)- propionitrile (1. Ig, 43%) as a solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Nitrophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F2G LTD; WO2006/123145; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts