Electric Literature of 17823-40-4, These common heterocyclic compound, 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 4-cyanophenylboronic acid (1.83 g, 8 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (1.0 g, 3.9 mmol), Pd2(dba)3 (0.18 g, 0.2 mmol), SPhos(0.16 g, 0.4 mmol) and K3PO4 (2.0 g, 8.7 mmol) in toluene (40 mL) was degassed and heated at about 120 C for about 16 hours. After cooled to room temperature, the mixture was filtered and washed with toluene. The filtrate was loaded on silica gel and purified by flash column using eluents of dichloromethane/hexane (10%to 40%). The desired fraction was collected and concentrated to give a white solid (Compound 10) (0.367 g, in 34% yield).
Statistics shows that 4-Bromo-2,3,5,6-tetrafluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 17823-40-4.
Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
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