Application of 630-18-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 630-18-2, name is Pivalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of nitrile (50 mmol), NaN3 (65 mmol), and Et3N¡¤HCl (150 mmol) in toluene (100 mL) was stirred at 110 C for 17-30 h (2b, 2f and 2l for 24 h; 2c and 2d for 17 h; 2e and 2j for 30 h). After cooling to r.t., the mixture was extracted with H2O (100 mL). To the aqueous layer, 36% HCl was added dropwise to acidic pH. After filtration, the solid was washed with water and dried under reduced pressure to give the expected tetrazole 2. The corresponding physical and spectroscopic data for tetrazoles 2 are detailed below.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pivalonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Behloul, Cherif; Bouchelouche, Kenza; Hadji, Yasmine; Benseghir, Saadia; Guijarro, David; Najera, Carmen; Yus, Miguel; Synthesis; vol. 48; 15; (2016); p. 2455 – 2460;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts