Electric Literature of 327056-73-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 327056-73-5 name is 3-Chloro-5-fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 19 (1.07 g, 5 mmol), 16 (1.3 g, 7.56 mmol), K2CO3 (2.07 g, 15.0 mmol) and NMP (10 mL) was stirred and heated to 110 C. for 6 h. The reaction mixture was cooled to RT and diluted with H2O (50 mL) and twice extracted with EtOAc. The combined organic extracts were washed sequentially with water and brine, dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with EtOAc/hexane (10:90) to afford 0.328 g of 31.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-5-fluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Roche Palo Alto LLC; US2007/88053; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts