147754-12-9, name is 4-Fluoro-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-Fluoro-2-methylbenzonitrile
Preparation 7; 2-(bromomethyl)-4-fluorobenzonitrile; A solution of 2-methyl-4-fluoro-benzonitrile (3.5 g, 25.9mmol) in 4OmL of carbon tetrachloride was treated with N-bromosuccinimide (4.6g, 25.9 mmol) and benzoylperoxide (157mg, 0.65 mmol). The mixture was heated to reflux for 3 hours, cooled to room temperature and allowed to stir overnight. The solids were filtered off and washed with carbon tetrachloride. The filtrate was condensed and purified by normal phase flash column chromatography on a 50 g silica gel column (5 – 50percent ethyl acetate/hexanes gradient). Two peaks separated. It was determined that the second eluting peak is the desired product. Pure fractions of this peak were pooled and concentrated in vacuo to yield 2-(bromomethyl)-4- fluorobenzonitrile (1.35g, 0.63 mmol, 25percent yield) as a white solid. 1H NMR (400 MHz, DMSO-dbeta) delta ppm 4.79 (s, 2 H), 7.44 (dt, J=8.59, 2.69 Hz, 1 H), 7.68 (dd, J=9.53, 2.55 Hz, 1 H), 8.01 (dd, J=8.59, 5.64 Hz, 1 H).
The synthetic route of 147754-12-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/53300; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts