Application of 5414-21-1, These common heterocyclic compound, 5414-21-1, name is 5-Bromovaleronitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-(2′-Aminopyrimidin-4′-yl)-1H-indole (80 mg, 0.38 mmol),KOH (30mg, 0.48mmol)With 5-bromopenteronitrile (0.23g, 1.43mmol)Miscible in DMF (6mL),And stirred at 40 C for 15 h,The resulting mixture was concentrated under reduced pressure to about 1/2 volume.Pour into H2O (20 mL),Extracted with EtOAc (15 mL¡Á3).The organic phase was combined and washed with saturated brine (20 mL).Anhydrous Mg2SO4 is dried,Silica gel layer filtration,The filtrate is evaporated to dryness.The resulting solid was dissolved in methanol (10 mL).Dry hydrogen chloride gas was passed at 0 C and stirred for 11 h, then evaporated to dryness.The resulting yellow solid was redissolved in methanol (10 mL).Slowly add 25% concentrated ammonia (1 mL) and stir for 3 h.The mixture is concentrated,Purified by column chromatography,Obtained a yellow solid (89 mg, yield 85%, a compound of formula I-26).
The synthetic route of 5414-21-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tsingtao Ocean Bio-pharmaceutical Institute Co., Ltd.; Jiang Tao; Dong Xueyang; Zhang Lijuan; Tong Sheng; Yin Ruijuan; Zhang Hailin; (26 pag.)CN108218838; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts