Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 193290-27-6, name is 3-(2-Hydroxyethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 3-(2-Hydroxyethyl)benzonitrile
To a cooled (0 C) solution of S15 (150 mg, 1.019 mmol) (which was prepared as described in Lee, B. C; Choe, Y. S.; Lee, K. H.; Kim, B. T.; Chi, D. Y. J. Labelled Compd. Rad. 2001, 44, S404) in CH2C12(8 mL) were added MsCl (0.16 mL, 2.038 mmol) and Et3N (0.43 mL, 3.057 mmol). After stirring for 0.5 h at 0 C, brine was added. The layers were separated and the aqueous layer was extracted with CH2C12. The combined organic layers were dried over anhydrous Na2S04and concentrated in vacuo. To a cooled (0 C) solution of the crude mixture in THF/DMF (4/1, 15 mL) were added triphenylmethylsilane (TrtSH) (1.13 g, 4.076 mmol) and NaH (60% dispersion in mineral oil, 163 mg, 4.076 mmol). After stirring for 16 h at 25 C, the reaction mixture was quenched by the addition of saturated NH4C1 solution and diluted with EtOAc. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over anhydrous Na2S04and concentrated in vacuo. The residue was purified by column chromatography (silica gel, EtOAc/hexanes = 1/30) to afford S16 (1.8 g, 94% for two steps)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 193290-27-6.
Reference:
Patent; HONG Jiyong; LUESCH Hendrik; WO2015/200699; A2; (2015);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts