Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151-18-8, name is 3-Aminopropanenitrile, A new synthetic method of this compound is introduced below., name: 3-Aminopropanenitrile
oBromonium iodobenzene(4.0 g, 14.1 mmol) in dimethylsulfoxide (40 mL) was added 3-aminopropionitrile(1.5 mL, 20 mmol), cuprous iodide (2.8 g, 15 mmol), cesium carbonate (7.0 g, 21.5 mmol) and N, N-dimethylglycine(1.5 g, 14 mmol), reacted at 70 C for 5 hours, quenched with water (40 mL), extracted with dichloromethane (40 mL x 3), dried over anhydrous sodium sulfate (Eluent: PE / EtOAc (v / v) = 2/1) to give 3.0 g of a pale yellow oil, and the residue was subjected to column chromatography , Yield: 94%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Liu, Bing; Huang, Jiuzhong; Zhang, Yingjun; Xue, Yaping; Xing, Wei; Xu, Juan; Wu, Zuping; Yu, Tianxi; (106 pag.)CN106432246; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts