5414-21-1, name is 5-Bromovaleronitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H8BrN
In a four-neck reactor equipped with a thermometer, in a nitrogen stream, 2-hydrazinobenzothiazole 10.0 g (60.5 mmol) of DMF were dissolved in 100 ml of DMF . To this solution, 41.8 g (304 mmol) of potassium carbonate, And 10.34 g of 5-bromovaleronitrile ( 60.6 mmol), and the whole was stirred at 60 C. for 8 hours. After completion of the reaction, The reaction solution was added to 20 C., and the mixture was poured into 1,000 ml of water, And extracted with 1000 ml of ethyl acetate. After drying the ethyl acetate layer with anhydrous sodium sulfate, Sodium sulfate was filtered off. Ethyl acetate was distilled off from the filtrate under reduced pressure by a rotary evaporator, A yellow solid was obtained. This yellow solid was dissolved in Siri Kagel column chromatography (N-hexane: ethyl acetate = 60: 40) To obtain 6.82 g of Intermediate T as a white solid (yield: 45.7%).
The synthetic route of 5414-21-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (78 pag.)JP6090514; (2017); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts