One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 623-03-0, Name is 4-Chlorobenzonitrile, formurla is C7H4ClN. In a document, author is Junge, Thorsten, introducing its new discovery. Computed Properties of C7H4ClN.
Asymmetric Hydrocyanation of N-Phosphinoyl Aldimines with Acetone Cyanohydrin by Cooperative Lewis Acid/Onium Salt/Bronsted Base Catalysis
alpha-Amino acids are of fundamental importance for life. Both natural and artificial alpha-amino acids also play a crucial role for pharmaceutical purposes. The catalytic asymmetric Strecker reaction still provides one of the most attractive strategies to prepare scalemic alpha-amino acids. Here we disclose a new concept for Strecker reactions, in which an achiral Bronsted base cooperates with a Lewis acid and an aprotic ammonium salt, which are both arranged in the same chiral catalyst entity. The described method could successfully address various long-standing practical issues of this reaction type. The major practical advantages are that (1) the N-protecting group is readily removable, (2) acetone cyanohydrin is attractive as cyanation reagent in terms of atom economy and cost efficiency, (3) an excess of the cyanation reagent is not necessary, (4) the new method does not require additives and (5) is performed at ambient temperature.
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